Treatment options for surgically resectable gastric cancer
The NCBI web site requires JavaScript to function. Surgery is the only curative therapy for gastric cancer. The standard recommendations for resectable gastric adenocarcinoma are free-margin surgery with at least D1 resection and the removal of a minimum of 15 lymph nodes.
The overall 5-year survival rate for resected gastric patients remains poor due to locoregional recurrence. The results of a large North American study Gastrointestinal Cancer Intergroup Trial INT reported that postoperative chemoradiotherapy conferred a survival advantage compared with surgery alone, which led to the regimen being adopted as a standard of care.
Thus, two successful strategies are available to improve outcomes in patients with localized gastric cancer. This article reviews data on adjuvant and perioperative treatment modalities for gastric cancer. The article discusses ongoing randomized adjuvant and perioperative trials that are designed to optimize chemotherapy regimens and also investigate combinations of chemotherapy and biologic agents.
Adjuvant and neoadjuvant treatment of gastric cancer
It is important to understand the mechanisms or pathways involved in gastric cancer development and metastasis. Identification of novel molecules pivotal to tumor biology may lead to new therapeutic approaches for this malignancy. National Center for Biotechnology Information , U. National Library of Medicine Rockville Pike , Bethesda MD , USA.
Homology BLAST Basic Local Alignment Search Tool BLAST Stand-alone BLAST Link BLink Conserved Domain Database CDD Conserved Domain Search Service CD Search Genome ProtMap HomoloGene Protein Clusters All Homology Resources Proteins BioSystems BLAST Basic Local Alignment Search Tool BLAST Stand-alone BLAST Link BLink Conserved Domain Database CDD Conserved Domain Search Service CD Search E-Utilities ProSplign Protein Clusters Protein Database Reference Sequence RefSeq All Proteins Resources Sequence Analysis BLAST Basic Local Alignment Search Tool BLAST Stand-alone BLAST Link BLink Conserved Domain Search Service CD Search Genome ProtMap Genome Workbench Influenza Virus Primer-BLAST ProSplign Splign All Sequence Analysis Resources Taxonomy Taxonomy Taxonomy Browser Taxonomy Common Tree All Taxonomy Resources Variation Database of Genomic Structural Variation dbVar Database of Genotypes and Phenotypes dbGaP Database of Single Nucleotide Polymorphisms dbSNP SNP Submission Tool All Variation Resources PubMed US National Library of Medicine National Institutes of Health.
Treatment options for surgically resectable gastric cancer — Albert Einstein College of Medicine
Search database All Databases Assembly Biocollections BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbGaP dbVar EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP Sparcle SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBook ToolKitBookgh UniGene Search term.
Abstract Format Summary Summary text Abstract Abstract text MEDLINE XML PMID List.
Treatment Options for Surgically Resectable Gastric Cancer | SpringerLink
Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Summary text Abstract text MEDLINE XML PMID List CSV Create File. Didn't get the message? Add to My Bibliography. Generate a file for use with external citation management software.
See comment in PubMed Commons below Curr Treat Options Oncol. Author information 1 Jack D. Weiler Hospital, Albert Einstein College of Medicine, Montefiore Medical Center, Eastchester Road, Rm 2S, Bronx, NY , USA.
Gastric Cancer Treatment (PDQ®)—Health Professional Version - National Cancer Institute
Abstract Surgery is the only curative therapy for gastric cancer. LinkOut - more resources Full Text Sources Springer Medical Stomach Cancer - MedlinePlus Health Information.
PubMed Commons home PubMed Commons. How to cite this comment: Supplemental Content Full text links.
Please review our privacy policy. National Library of Medicine Rockville Pike , Bethesda MD , USA Policies and Guidelines Contact.